Amlodipine
Amlodipine 2.5mg, 5mg and 10mg tablets, taken for hypertension and angina. A calcium channel blocker.
- Category
- Heart & Blood Pressure
- Active ingredient
- Amlodipine
- Route
- Oral
- Form
- Tablet
- Strengths
- 2.5/5/10mg
You will receive a quality generic, depending on stock.
Shipped in a discreet, unmarked envelope.
Details
- Conditions
- Hypertension · Angina
- Therapeutic Class
- Calcium channel blocker
- Pharmacological Class
- Dihydropyridine
- Minor Side Effects
- Ankle swelling, Flushing
- Moderate Side Effects
- Dizziness, Fatigue
- Dosage Forms
- Tablet
- Administration Route
- Oral
- Originator
- Pfizer
- Onset Time
- 30–60 minutes
- Duration
- 24 hours
- Storage Instructions
- Store at room temperature.
- Drug Interactions
- Simvastatin, Cyclosporine
- Age Restrictions
- Use as directed by a specialist.
What you will receive
Amlodipine is a generic medicine sold under the name of its active ingredient, Amlodipine.
- The manufacturer depends on what is in stock when your order ships.
- It contains the same active ingredient, at the same strength, as the brand-name versions.
FAQ
Which Amlodipine strengths can I order?
Amlodipine comes as tablets in 2.5mg, 5mg and 10mg. Packs range from 30 up to 360 tablets for 2.5mg and 5mg, and 10 up to 360 for 10mg. You receive generic amlodipine. Each page shows the price per tablet in Hong Kong dollars, and larger packs cost less per tablet.
How is Amlodipine sent to Hong Kong?
Amlodipine ships by tracked courier in 5 to 9 business days with online tracking, or by standard airmail in 14 to 21 business days, untracked. Very large orders over 120 units may be split into several parcels. Every parcel is plain and unbranded.
Are generic versions of Amlodipine bioequivalent to the reference product?
Generic formulations must demonstrate bioequivalence through rigorous testing to ensure they deliver the same amount of active ingredient into the bloodstream at the same rate as the originator compound.
Why are multi-source formulations more economical than original brands?
Multi-source equivalents facilitate market competition, which reduces costs by addressing initial research and development expenses while maintaining high-quality manufacturing standards.
Does the physical formulation variance affect absorption?
While binders or fillers in the pill may differ between brands, the active API must meet strict regulatory standards to ensure equivalent absorption and clinical efficacy in the human body.
What factors influence the stability of the medication during transit?
Temperature, light exposure, and humidity influence stability, requiring controlled environments and setreatment packaging throughout the shipping process to maintain the chemical integrity of the API.
Will this medication trigger positive results on drug tests?
Medications do not influence standard occupational or athletic drug screening panels, though individuals should inform testing facilities of all current therapeutic agents for accuracy in medical reporting.
About Amlodipine
Amlodipine Pharmacological Profile
Amlodipine manifests as a dihydropyridine calcium channel blocker available in oral pill form. Standard available concentrations include 2.5mg, 5mg, and 10mg preparations for standardized clinical intervention. This generic formulation functions as a long-acting peripheral vasodilator that acts directly on vascular smooth muscle cells.
Physicians categorize this agent within the cardiovascular therapeutic class for the management of hypertensive states and myocardial ischaemia. It facilitates blood pressure reduction through the strategic inhibition of calcium ion influx into cardiac and vascular smooth muscle, promoting arterial lumen dilation and reducing peripheral vascular resistance.
Cellular Mechanism of Action
Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. It binds to the dihydropyridine binding site of the L-type voltage-gated calcium channel. This blockade prevents the activation of the contractile machinery within these cells. Arterial blood vessels dilate as a direct result of decreased cytosolic calcium concentrations. This mechanism decreases total peripheral resistance and moderates systemic blood pressure levels. The molecule displays slow association and dissociation kinetics, which leads to a gradual onset of activity and a sustained duration of action.
Regulatory Indications and Approval
It also maintains approval for documented cases of vasospastic angina, also known as Prinzmetal's or variant angina. All indicated uses follow the labels verified by the regulatory framework within the Hong Kong Special Administrative Region.
Contraindications
Pregnancy and Developmental Risks
Amlodipine remains in a clinical category requiring medical oversight during gestation. The medication may cross the placental barrier and exert physiological effects on the foetus.
Hypersensitivity
Individuals with a known allergy to dihydropyridine calcium channel blockers must avoid this agent. Hypersensitivity reactions may manifest as dermatological or systemic immunological responses.
Adverse Events
Common Adverse Symptoms
Peripheral oedema-the accumulation of fluid in the lower extremities-represents a frequent clinical observation. Patients may experience dizziness, fatigue, or palpitations as the cardiovascular system adjusts to modified vascular resistance. Flushing of the skin also occurs due to superficial vasodilation.
Serious Adverse Symptoms
Hypotension-an excessive drop in arterial blood pressure-requires immediate professional evaluation. Myocardial infarction or severe arrhythmias arise in rare clinical contexts. Seek immediate medical assistance if symptoms of severe chest discomfort or lightheadedness manifest during the course of therapy.
Interactions
Concomitant use of strong CYP3A4 inhibitors may increase systemic exposure to the compound. Interactions with grapefruit juice or other inhibitory substances potentially alter the metabolic breakdown of the medication. Avoid combining this agent with other antihypertensive drugs unless a doctor specifically coordinates the therapeutic regimen.
Clinical Administration
Administered orally via standardized pills once daily. Maintain consistency in the timing of administration to ensure steady state concentrations in the plasma.
Storage Conditions
Store the pills at room temperature away from direct light and moisture. Keep the medication in original packaging to prevent environmental degradation. Refer to local Hong Kong pharmacy protocols for the disposal of expired or unused pharmaceutical units.
Pharmacological Glossary
L-type calcium channel: A protein complex that mediates the entry of calcium into muscle cells to trigger contraction.
Vasodilation: The widening of blood vessels resulting from the relaxation of smooth muscle cells within the vessel walls.
Peripheral vascular resistance: The force that blood must overcome to pass through the circulatory system, primarily controlled by arterial diameter.
Pharmacodynamics: The study of the physiological effects of a chemical compound on the body and the mechanisms of drug action.
Sources
- Amlodipine: MedlinePlus Drug Information — National Library of Medicine
- High blood pressure - NHS — NHS