Nexavar
Sorafenib 200mg tablets sold as Nexavar, used for advanced kidney cancer, inoperable liver cancer and a type of thyroid cancer, in packs of 30 to 120.
All strengths and pack prices
| Strength | Pack | Price | Per tablet |
|---|---|---|---|
| 200mg | 30 tablets | $191.40 | $6.38 |
| 200mg | 60 tablets | $361.80 | $6.03 |
| 200mg | 90 tablets | $535.50 | $5.95 |
| 200mg | 120 tablets | $704.40 | $5.87 |
- Category
- Oncology Support
- Active ingredient
- Sorafenib
- Route
- Oral
- Form
- Tablet
- Strengths
- 200mg
You will receive a quality generic equivalent, depending on stock.
Shipped in a discreet, unmarked envelope.
Details
- Conditions
- Advanced renal cell carcinoma · Hepatocellular carcinoma · Differentiated thyroid carcinoma
- Therapeutic Class
- Multikinase Inhibitor
- Pharmacological Class
- Antineoplastic
- Minor Side Effects
- Fatigue, Skin rash, Hair thinning
- Moderate Side Effects
- Diarrhoea, Hand-foot skin reaction, Hypertension
- Dosage Forms
- Tablet
- Administration Route
- Oral
- Originator
- Bayer
- Storage Instructions
- Store at room temperature in a dry place.
- Drug Interactions
- Warfarin, Dexamethasone
What you will receive
Nexavar is the originator brand name, made by Bayer. We use it to identify the medicine; the pack you receive is a generic equivalent, not the original Nexavar.
- The same active ingredient (Sorafenib) at the same strength.
- The exact brand supplied depends on what is in stock when your order ships.
FAQ
Which Nexavar strengths and pack sizes can I order?
Nexavar comes as 200mg tablets, in packs of 30 to 120 tablets. It is generic sorafenib, not the original Nexavar. Larger packs cost less per tablet.
How is Nexavar delivered to Hong Kong for a long course?
For a long course of Nexavar, tracked courier takes 5 to 9 business days with online tracking, while standard airmail takes 14 to 21 business days and is untracked. Orders over 120 units may be split into several parcels.
Is Nexavar the same as sorafenib?
Nexavar is the brand name for sorafenib. The 200mg tablets sold on this page are generic sorafenib, so what is inside matches the original in active ingredient and 200mg strength, while the inactive ingredients in the tablet can differ.
Can I take sorafenib with food?
Food is the one thing to plan around: sorafenib is taken on an empty stomach, an hour before a meal or two hours after one. Tablets are swallowed whole with water rather than split or chewed, and both daily doses stay at roughly the same times.
How long will I stay on sorafenib?
Sorafenib is a long-term treatment, usually continued for months for as long as it is helping. Tablets keep being taken during good spells, and the dose can be reduced or paused for a time if the side effects are difficult to manage.
What is hand-foot skin reaction?
Sorafenib is known for it: sore, red, swollen or peeling skin on the palms and soles. Most people who get it notice it within the first few weeks, and walking or holding a cup can hurt while it lasts.
What should I avoid while taking sorafenib?
Two things lower the amount of sorafenib in the blood: St John's wort, and the antibiotic neomycin. Both are better left out until treatment ends.
About Nexavar
A tablet for three advanced cancers
Sorafenib, sold as 200mg Nexavar tablets, is a kinase inhibitor — a medicine that blocks particular proteins inside cells. It treats kidney cancer that has spread (advanced renal cell carcinoma), liver cancer that cannot be operated on (hepatocellular carcinoma), and differentiated thyroid cancer that has spread and stopped responding to radioactive iodine. Two things happen at once: signals that push cancer cells to divide are blocked, and the fine network of vessels a tumour builds to feed itself is disturbed. Treatment is long term rather than a short course, dosed twice daily, once on waking and once at night. Sorafenib is taken on an empty stomach, an hour before a meal or two hours after, and swallowed whole. Feeling well is no reason to stop, since it works only while it is being taken; if side effects become hard to live with, the dose can be lowered or paused for a while.
Side effects to expect
Hands and feet often react first: the skin on the palms and soles turns red, feels tender or swollen, and may blister or peel. This hand-foot skin reaction is most likely in the opening weeks. Rash, diarrhoea, tiredness, nausea, a sore mouth, appetite and weight loss, and thinning hair are common too, and blood pressure tends to rise during treatment. Rarer and serious: bleeding that will not stop, chest pain or an irregular heartbeat, and severe blistering skin reactions — all of which need urgent treatment.
Herbal remedies, pregnancy and breastfeeding
St John's wort, the herbal remedy some people take for low mood, can lower the amount of sorafenib in the blood; the antibiotic neomycin can reduce it too. Sorafenib can harm an unborn baby. Women who could become pregnant need effective contraception during treatment and for six months after the final dose, and men with a partner who could become pregnant for three months. Breastfeeding is not continued during treatment or for two weeks after the last tablet.
Packs for a long course
Because the tablets are taken every day for months, packs of 30 to 120 tablets match the way a course runs, and a larger pack means fewer reorders. For more on the ingredient itself, see sorafenib.
Sources
- Sorafenib: MedlinePlus Drug Information — MedlinePlus / U.S. National Library of Medicine
- DailyMed - Search Results for sorafenib — DailyMed / U.S. National Library of Medicine