Vastarel
Vastarel

1.25
Vastarel is an add-on oral medication indicated for the symptomatic treatment of adult patients managing inadequately controlled stable angina pectoris.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Trimetazidine
Reference Brand
Trimetazidine
Product Origin
Generic Alternative
Reference Manufacturer
Servier
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Heart & Blood Pressure
Product Category
Anti-anginal
Pharmacological Class
Metabolic agent
Clinical Indications
Angina pectoris, Dizziness of vascular origin, Tinnitus
Manufacturer Description
Vastarel is an add-on oral medication indicated for the symptomatic treatment of adult patients managing inadequately controlled stable angina pectoris.
Mechanism of Action
Trimetazidine functions as a cellular anti-ischemic agent, optimizing cardiac energy metabolism by shifting it from fatty acid oxidation toward glucose oxidation, preserving intracellular ATP during hypoxic events.
Route of Administration
Oral
Onset Time
Within 2 hours
Duration
8–12 hours
Contraindications
Parkinson's disease, Movement disorders, Severe renal impairment
Severe Adverse Events
Tremors, Gait instability, Movement abnormalities
Common Side Effects
Nausea, Vomiting, Abdominal discomfort
Uncommon Side Effects
Diarrhea, Headache, Weakness
Drug Interactions
Levodopa
Pregnancy Safety Warnings
Not recommended during pregnancy.
Age Restrictions
Not indicated for pediatric patients.
Storage Guidelines
Store in its original packaging in a cool, dry place.
Related Products
Ranolazine, Ivabradine

Vastarel FAQ

What is the difference between Vastarel and generic trimetazidine?

Vastarel is a branded formulation of trimetazidine that contains 20 mg of the active ingredient per capsule. Generic versions contain the same amount of trimetazidine but may differ in inactive ingredients, appearance, or packaging.

Can I take Vastarel if I have a history of migraine?

Trimetazidine is not known to trigger migraines, but individual responses vary. Discuss your migraine history with a healthcare professional before starting the medication.

How quickly can I expect relief from angina after beginning Vastarel?

Clinical improvement often becomes noticeable within a few days of regular dosing, but full therapeutic benefit may take several weeks as the heart adapts to the metabolic changes.

Are there any dietary restrictions while taking Vastarel?

There are no specific food restrictions, but maintaining a balanced diet low in saturated fats supports overall heart health and complements the medication’s effects.

Will Vastarel appear on a standard drug test for employment or sports?

Trimetazidine is not part of routine occupational drug screens, but it is listed on the World Anti-Doping Agency (WADA) prohibited list. Athletes should verify sport-specific regulations before use.

Can I travel with Vastarel tablets in my hand luggage?

Yes, you may carry your prescribed capsules in hand luggage, provided they are in their original packaging with a clear prescription label. Keep them easily accessible for security inspection.

What should I do if I accidentally swallow two capsules at once?

Do not induce vomiting. Seek immediate medical attention or contact a poison control center for guidance, as the dosage may exceed the recommended amount.

Is Vastarel safe for people with mild liver disease?

Mild hepatic impairment generally does not require dose modification, but liver function should be evaluated periodically, and any concerns discussed with a prescriber.

How does Vastarel compare to other anti-anginal drugs like beta-blockers?

Beta-blockers reduce heart rate and contractility, while Vastarel improves the heart’s metabolic efficiency without affecting heart rate. They can be used together, but a clinician should tailor therapy to each patient’s needs.

What is the typical cost difference between Vastarel and generic trimetazidine in Hong Kong?

Brand-name products often carry a higher price due to branding and distribution costs. Generic equivalents usually offer a lower-cost option, though exact pricing varies among pharmacies and insurance coverage.

What is Trimetazidine?

Interacting with the cell’s internal energy production, Trimetazidine operates as a metabolic agent designed to support heart muscle function. By shifting the way heart cells process energy, this compound helps the cardiac muscle maintain its rhythm and function, particularly under conditions of stress or reduced blood flow. It is the active molecular component found in various formulations historically associated with brand names like Vastarel.

As a therapeutic substance, it is classified as a metabolic modulator. It does not act directly on blood pressure or heart rate like other common cardiovascular agents, but rather focuses on protecting cell integrity during periods of oxygen imbalance. This distinction makes it a unique tool in the management of specific chronic conditions related to the circulatory system.

Patients in Hong Kong and other jurisdictions may encounter this ingredient as a standard option for sustained therapy. It is synthesized within strict pharmacological standards to ensure consistent delivery, acting upon the cellular pathways that govern glucose and fatty acid metabolism.

Formulations and Product Availability

Trimetazidine is typically available in immediate-release and modified-release tablets. In the local clinical landscape of Hong Kong, formulations often arrive as both branded and generic options. Branded iterations are commonly recognized by their registered names, while generic versions contain the identical active ingredient, produced to match the efficacy standards of the leading version.

These tablets are designed for oral administration. The modified-release versions are particularly common, as they allow for a steady release of the compound into the bloodstream over time. Whether choosing a branded product or a generic equivalent, the pharmaceutical quality and chemical structure of Trimetazidine remain consistent, as they are held to established regulatory norms regarding potency and bioavailability.

Clinical Indications and Application

Metabolic support remains the primary objective for this substance. It is commonly applied in the following scenarios:

  • Management of stable angina pectoris to reduce frequency of physical discomfort.
  • Support for patients where conventional cardiovascular therapies are insufficient or poorly tolerated.
  • Addressing chronic symptoms related to ischemic heart issues.
  • Assisting in the stabilization of cellular energy levels for individuals with persistent fatigue or exercise limitations.

These applications focus on long-term health management rather than immediate symptom relief for acute emergencies. Clinical pathways often integrate Trimetazidine into a broader strategy to assist the heart in managing daily physical demands effectively.

Cellular Energy Modulation

Energy production within heart cells relies on the breakdown of fatty acids and glucose. Usually, the heart prefers fatty acids; however, this process requires significant amounts of oxygen. During periods of temporary oxygen shortage, this process becomes inefficient and can lead to cellular instability.

Trimetazidine gently inhibits the enzymes responsible for fatty acid oxidation. By doing so, it forces the heart cells to prioritize the metabolism of glucose, which requires less oxygen to produce the same amount of cellular energy. This metabolic optimization allows the cardiac tissue to function more efficiently even when blood flow is inhibited, thereby addressing the clinical manifestations associated with restricted coronary supply.

Safety Profile

Common Reactions

Patients may occasionally experience mild gastrointestinal sensations such as nausea, abdominal discomfort, or indigestion. Some individuals report a feeling of transient weakness or mild headaches during the initial phase of starting this compound.

Serious Reactions

Though infrequent, rare instances of involuntary movement disorders-such as tremors, unsteady gait, or rigid muscles-have been observed. Individuals noting any unexpected changes in motor control or neurological symptoms should prioritize a review of their treatment path with a medical professional immediately.

Contraindications

This substance is generally not recommended for individuals with severe kidney function impairment. It is also advised against for those carrying high sensitivities to the chemical profile of the compound or those experiencing significant movement-related neurological disorders, such as Parkinson’s disease.

Interaction Awareness

While this compound has a distinct metabolic profile, users should be aware that concurrent use with other substances-particularly those affecting the central nervous system or liver enzymes-may result in additive effects. Always review the specific patient information leaflet provided with your medication packaging for an exhaustive list of known chemical interactions.

Considerations for Ongoing Use

The administration of Trimetazidine is typically long-term, requiring consistent, daily adherence to achieve its metabolic effects. Variable storage conditions can affect the stability of the tablets, so keeping them in their original packaging at room temperature, away from moisture and direct heat, is essential. For detailed usage, frequency of dosing, and specific administration protocols, refer to the specific medication’s clinical information leaflet.

Glossary

Metabolic modulator
A substance that alters the biochemical processes of a cell to improve energy efficiency without changing heart rate or blood pressure.
Angina pectoris
A clinical condition characterized by chest pain or discomfort caused by reduced oxygen delivery to the heart muscle.
Ischemia
A restricted blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular survival.
Fatty acid oxidation
A biological process where the body breaks down fats to generate cellular energy, which acts as a primary fuel source for the heart.

Clinical Disclosure

This overview provides general educational information regarding Trimetazidine and does not constitute medical advice or a recommendation for use. Individual medications vary in dosage, strength, and specific formulation requirements. No liability is assumed for the clinical results of using this substance. Patients should always consult the specific labeling provided with their current medication and speak with a licensed healthcare professional in Hong Kong regarding their unique health history and treatment requirements before starting or stopping any therapy.

Categories