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Abiraterone acetate is a daily tablet for advanced prostate cancer that lowers the androgens feeding the tumour; PockDose sells it as Abiraterone 250mg tablets.
Abiraterone acetate
250mg
Abiraterone 250mg tablets are a hormone treatment for prostate cancer: they lower the androgens the cancer grows on, and come in packs of 120 or 240.
Abiraterone acetate is a prostate cancer medicine. It is used when the cancer is advanced — it has spread beyond the prostate, or has come back after surgery or radiotherapy — and when it is castration-resistant, meaning it keeps growing even though testosterone has already been pushed down to very low levels. It is usually taken with a hormone injection that keeps the testicles switched off, or after surgery to remove them, and with a low dose of prednisone or prednisolone.
Abiraterone acetate is a prodrug: the body converts it into abiraterone after the tablet is swallowed. That active form blocks CYP17A1, an enzyme the adrenal glands, the testicles and the tumour cells themselves use to build androgens such as testosterone from cholesterol. With the enzyme blocked, production falls away across the body rather than in one place, and the cancer cells lose much of the hormone signal they rely on to multiply. Testosterone does not drop to zero, but it falls sharply while the treatment continues.
PockDose sells Abiraterone as 250mg tablets. The daily dose is four of these tablets taken together. Food raises the amount the body absorbs, so the daily dose goes down on an empty stomach: at least an hour before a meal, or two hours after one. Swallow the tablets whole with water rather than crushing or chewing them, and keep them somewhere cool and dry rather than in direct heat.
Tiredness, joint aches, hot flushes, high blood pressure, swollen legs and feet from fluid retention, low potassium, diarrhoea, a cough and urinary infections are the effects that come up most. Several of them trace back to the way the blocked enzyme pathway changes the body's salt and water balance.
Low potassium can show up as muscle cramps or weakness and a fluttering heartbeat, and blood pressure often creeps up while treatment continues. Liver enzymes are checked during treatment because abiraterone can raise them and, occasionally, cause serious liver injury. Yellowing of the skin or eyes, dark urine and pain in the upper right abdomen point to liver trouble.
Abiraterone is broken down by the liver enzyme CYP3A4, and medicines that speed that enzyme up — rifampicin, rifabutin, carbamazepine, phenytoin and St John's wort among them — lower the amount of abiraterone in the blood. Abiraterone itself blocks CYP2D6, so medicines cleared by that route, including some antidepressants, antipsychotics and the cough medicine dextromethorphan, can build up while it is being taken.
Abiraterone acetate can be ordered online from PockDose with delivery to Hong Kong. The page lists Abiraterone 250mg tablets, a plain version of the ingredient. Payment can be made by Visa, Mastercard or American Express on a secure, encrypted page, or with Bitcoin or Ethereum.
The price depends on the strength and pack size you choose. The Abiraterone page shows current prices in HKD or the currency you select.
Zytiga is a brand name of abiraterone acetate, which is also sold as Abirapro. Here, abiraterone acetate can be bought online as abiraterone tablets. These are generics, not the original brand.
Abiraterone acetate is noted as interacting with CYP3A4 inducers and CYP2D6 substrates. Abiraterone tablets in 250mg are sold here.
No. Abiraterone is a hormone treatment rather than chemotherapy: it does not attack dividing cells directly, it blocks an enzyme the body uses to make androgens such as testosterone. It is swallowed as tablets every day, and the effect builds steadily while treatment continues rather than arriving in cycles.
Yes, abiraterone is used with a low daily dose of a steroid, usually prednisone or prednisolone. Blocking CYP17A1 also lowers the body's own cortisol production, and the daily steroid covers that while easing some of the hormone-related effects. The two are taken as one treatment.
The 250mg tablets go down on an empty stomach — at least one hour before a meal, or two hours after one. Food, and a high-fat meal in particular, increases how much abiraterone the body absorbs, which is why the timing is kept steady from day to day. Water is fine.
Often, yes. Because the enzyme block lets mineralocorticoids build up, the body keeps more salt and water than it should. That shows up as higher blood pressure, a fall in potassium and puffy ankles or feet, and none of it needs to feel like anything. Blood pressure and potassium are checked at regular visits for that reason.