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Bempedoic acid is a non-statin tablet that lowers LDL cholesterol by blocking an enzyme in the liver; PockDose lists plain Bempedoic Acid and Nexletol, both 180mg tablets.
Bempedoic acid
180mg
Bempedoic acid 180mg tablets, taken once a day to lower LDL cholesterol and cut the risk of heart attack and stroke, sold in packs of 30 to 180.
The liver builds cholesterol through a long series of steps. Statins act on one enzyme in that chain; bempedoic acid acts on another, ATP citrate lyase, which comes earlier. The tablet is a prodrug, meaning it is inactive until an enzyme turns it into the working form. That enzyme is found in the liver but not in muscle, so the drug does its work in the liver only. As the liver makes less cholesterol it takes up more LDL from the blood, and the LDL reading falls.
Adults whose LDL stays above target even on the highest statin dose they can tolerate are the main group, along with adults who cannot take a statin at all. Bempedoic acid is also used for familial hypercholesterolaemia (high cholesterol inherited in families), for high LDL together with high triglycerides, and to lower the risk of heart attack and stroke in adults with heart disease or at high risk who cannot take statins. It can be used alone, with a statin, or with ezetimibe.
Bempedoic Acid tablets and Nexletol are both 180mg tablets, taken once a day, and both contain bempedoic acid. The only difference you will see is the name on the box, so choose by which one you are used to. Brand-name Nexlizet is a separate combination with ezetimibe and is not one of these two.
Gout is the one to know about. Uric acid climbs within the first weeks and stays up while the tablets continue, and people who have had gout before are the most likely to be hit. Tendon rupture is the other, mostly the Achilles tendon or shoulder, with higher odds over the age of 60, with corticosteroid or fluoroquinolone antibiotic use, in kidney failure, or after earlier tendon trouble.
Muscle spasms, back pain and pain in the arms and legs are more everyday complaints. Liver enzymes can rise, haemoglobin can dip and kidney readings can shift, which is why blood tests are used to follow it. Higher doses of simvastatin and pravastatin are held back because bempedoic acid pushes their levels up. Pregnancy and breastfeeding rule it out.
Bempedoic acid can be ordered online from PockDose with delivery to Hong Kong. The page lists plain Bempedoic Acid tablets in 180mg and generic Nexletol at 180mg. Payment can be made by Visa, Mastercard or American Express on a secure, encrypted page, or with Bitcoin or Ethereum.
Prices vary between the two bempedoic acid products and between pack sizes. Every product page lists its current prices in HKD or in the currency you choose.
PockDose does not ask you to upload a prescription when you order bempedoic acid. See the ordering FAQ for details.
Nexletol is a brand name of bempedoic acid, which is also sold as Nilemdo. Here, bempedoic acid can be bought online as generic Nexletol and bempedoic acid tablets. These are generics, not the original brand.
Both listings are 180mg bempedoic acid tablets, so the active ingredient, strength and form match. What differs is the name they are sold under and the pack in which you order them.
Yes. It was developed to add to a statin when LDL stays high, and it can be taken with ezetimibe as a separate tablet. Nexlizet is simply the two active ingredients, bempedoic acid and ezetimibe, in a single tablet.
Uric acid, liver enzymes and the blood count are the main ones, because bempedoic acid can raise the first two and lower haemoglobin a little. Kidney function is followed too, and the cholesterol panel shows whether it is working.