Itraconazole

Itraconazole is a triazole antifungal for nail and skin infections, thrush and deeper fungal infections; PockDose lists itraconazole capsules in 100mg and 200mg and generic Sporanox in 100mg.

Itraconazole

Itraconazole

100/200mg

Itraconazole is a triazole antifungal capsule in 100mg and 200mg, taken for fungal nail infections, ringworm, thrush and deeper fungal infections.

from $1.17 / capsule View

Sporanox

Itraconazole

100mg

Sporanox here is generic itraconazole 100mg capsules for fungal infections of the nails, skin, mouth and throat, and for deeper fungal infections, in packs of 10 to 50.

from $5.00 / capsule View

How it acts on fungus

Fungi build their cell membranes from ergosterol, and itraconazole blocks an enzyme they need to make it. The membrane starts to leak and the fungus stops growing. The drug is fat-soluble, so it collects in skin, nails and mucous linings and stays there after the last capsule.

What it is used for

Toenail fungus is the usual reason to buy it. The same capsule is also used for ringworm and other tinea infections, for pityriasis versicolor (pale or brown scaly patches), and for thrush in the mouth, throat or vagina. At the far end sit deep infections such as histoplasmosis, blastomycosis and aspergillosis, usually breathed in from soil, dust or mould spores.

The listings

Itraconazole comes as capsules in 100mg and 200mg. Sporanox, the generic Sporanox listing, is the same ingredient in 100mg capsules. Choose by name and strength; the capsules in both listings are taken the same way. Itraconazole is also made as a liquid, which is absorbed differently and is taken on an empty stomach, whereas capsules go with a full meal.

How long a course lasts

Nails are where people go wrong. A treated nail grows out slowly and can look clean while fungus is still underneath; stop at that point and the infection is often back within months. Vaginal thrush, by contrast, may need only a short course, ringworm a little longer, and deep infections are treated for months.

Interactions and cautions in more depth

Anyone on simvastatin for cholesterol cannot simply add itraconazole. The reason is CYP3A4, a liver enzyme that itraconazole strongly slows, so medicines that rely on it for breakdown build up. Lovastatin, oral midazolam and triazolam (sedatives), pimozide, quinidine, dofetilide (an antipsychotic and two heart-rhythm medicines) and methadone are on the same no-list. Blood thinners and some cancer medicines need adjusting, and acid reducers cut how much capsule gets absorbed.

The heart is the other limit: itraconazole can weaken its contractions, so heart failure rules it out. The liver can be hurt in some people. Day to day, expect nausea, stomach pain, diarrhoea, headache or a bad taste. It is avoided in pregnancy.

Sources

  1. Itraconazole: MedlinePlus Drug Information — National Library of Medicine
  2. Climate and Fungal Diseases - CDC — Centers for Disease Control and Prevention
Where can I order Itraconazole for delivery in Hong Kong?

You can order itraconazole online with delivery to Hong Kong. The range includes generic Sporanox as 100mg capsules and Itraconazole capsules in 100mg and 200mg. If a parcel does not arrive within the delivery window or arrives damaged, it is sent again free, or refunded if that is not possible.

How are Itraconazole prices shown?

It depends on the product, strength and pack size. Each of the two itraconazole products listed here shows its current prices in HKD or the currency you select.

Do I need a prescription to order Itraconazole?

PockDose does not ask you to upload a prescription when you order itraconazole. See the ordering FAQ for details.

What brand names does itraconazole have?

Sporanox is a brand name of itraconazole, which is also sold as Candiforce and Itrasys. Here, itraconazole can be bought online as generic Sporanox and itraconazole capsules. These are generics, not the original brand.

What is the difference between itraconazole and fluconazole?

Both are triazole antifungals, but they do different jobs. Itraconazole also covers moulds such as Aspergillus and is the one usually used for nails, while fluconazole is more often used for yeast infections such as thrush. Itraconazole interferes with more medicines, because it blocks a liver enzyme more strongly.

Can itraconazole capsules be opened or crushed?

Swallow them whole. Breaking the capsule open, chewing it or crushing it changes how the medicine is absorbed, so take it with a full meal and a glass of water instead.

Does itraconazole stay in the body after the course ends?

Yes, for a while. After the last capsule the drug stays in skin and nails for weeks to months, so an infected nail can go on improving. Then the nail has to grow out, which is slow.