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Methotrexate is a once-weekly tablet for rheumatoid arthritis, psoriasis and some cancers; the 2.5mg strength is the single listing you can order here.
Methotrexate
2.5mg
Methotrexate 2.5mg tablets are used for rheumatoid arthritis, psoriasis and some cancers; this antimetabolite listing comes in packs of 30, 60, 90 or 120 tablets.
Methotrexate is an antimetabolite: it blocks dihydrofolate reductase, the enzyme that turns folic acid into the form cells need to build DNA. Cells that divide quickly feel this most, which is why it calms the overactive immune cells behind rheumatoid arthritis, slows the fast skin-cell turnover of psoriasis, and is used at higher doses in some cancers. In rheumatoid arthritis it acts as a disease-modifying drug, working on joint damage rather than only on pain.
Methotrexate tablets in 2.5mg are the only strength and form in this shop's range, and the same tablet appears in the autoimmune care group. For rheumatoid arthritis and psoriasis the week's dose goes in on one chosen day — not every day, which is a serious mistake with this medicine. A weekly amount is built from several 2.5mg tablets. Folic acid is often taken on the days in between to cut down mouth ulcers and nausea. Give it several weeks before judging the effect on joints, and a few months for the full benefit.
Mouth ulcers, nausea, headache, tiredness, a flat appetite, loose stools and thinning hair are the effects people notice most, and some of them ease as the body adjusts. Rarer but more serious: a fall in blood cells, showing as unusual bruising or bleeding, a sore throat or fever; liver inflammation, which can yellow the skin or eyes; and lung inflammation, which appears as a dry cough or breathlessness that will not settle and needs urgent attention. Methotrexate is not used in pregnancy, because it can harm a developing baby.
NSAIDs such as ibuprofen and naproxen, some penicillins and probenecid all slow the body's handling of methotrexate, pushing levels higher than intended. Trimethoprim and other folate-blocking drugs add to the effect on blood cells. Alcohol piles extra strain on the liver, so a heavy drinking habit and methotrexate are a bad pairing.
Store the blister pack somewhere dry and out of direct sunlight, away from radiators and kitchen heat, and where children cannot reach it. The day of the week matters more than the hour, so pick one you will not forget.
Methotrexate can be ordered online with delivery to Hong Kong. The product here is Methotrexate tablets in 2.5mg. A tracked courier brings orders to Hong Kong in 5 to 9 business days, with online tracking included.
The price depends on the strength and pack size you choose. The Methotrexate page shows current prices in HKD or the currency you select.
Rheumatrex is a brand name of methotrexate, which is also sold as Metoject and Trexall. Here, methotrexate can be bought online as methotrexate tablets. These are generics, not the original brand.
Methotrexate is noted as interacting with NSAIDs, penicillins and probenecid. Methotrexate tablets in 2.5mg are sold here.
For rheumatoid arthritis and psoriasis the whole week's dose goes in on one day, usually the same day each week. Spreading it across the week, or taking a tablet every day, lets far too much of the medicine build up. The 2.5mg strength allows a weekly amount to be made up from a few tablets.
Alcohol and methotrexate both put pressure on the liver, and regular or heavy drinking raises the risk of liver damage during treatment. If you also take NSAIDs such as ibuprofen, the strain on the liver and kidneys is greater again. Keeping alcohol low is the safer pattern.
Not quickly. Stiff joints may loosen after several weeks, and psoriasis patches often fade over about the same time. The full effect can take a few months, so a verdict in week one tells you nothing.
No. Methotrexate interferes with cell division and can cause miscarriage or birth defects, so it is not used during pregnancy. Men are also advised not to father a child while taking it, and the same caution applies when a couple is trying to conceive.
Methotrexate injections exist in some markets, given under the skin or into a muscle, and are sometimes used when tablets upset the stomach. The listing here is the 2.5mg tablet only.