Antabuse
Antabuse

0.62
Antabuse is a deterrent medication utilized in the management of alcohol dependence to encourage abstinence.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Disulfiram
Product Origin
Generic Alternative
Reference Manufacturer
Odyssey Pharmaceuticals
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Addiction Recovery
Product Category
Alcohol dependence treatment
Pharmacological Class
Aldehyde dehydrogenase inhibitor
Clinical Indications
Alcohol dependence
Manufacturer Description
Antabuse is a deterrent medication utilized in the management of alcohol dependence to encourage abstinence.
Mechanism of Action
Disulfiram blocks the enzyme that breaks down alcohol, leading to an accumulation of acetaldehyde that causes severe physical discomfort upon alcohol consumption.
Route of Administration
Oral
Onset Time
12 hours
Duration
Up to 2 weeks post-discontinuation
Contraindications
Recent alcohol consumption, Severe cardiovascular disease
Severe Adverse Events
Severe reaction to alcohol consumption, Hepatic impairment
Common Side Effects
Metal taste, Drowsiness
Uncommon Side Effects
Skin rash, Headache
Drug Interactions
Alcohol, Metronidazole
Pregnancy Safety Warnings
Use with extreme caution.
Age Restrictions
Adults only
Storage Guidelines
Store away from light.
Related Products
Naltrexone, Acamprosate

Antabuse FAQ

Does Generic Antabuse (Disulfiram) offer the same bioequivalence as the originator?

Generic Antabuse (Disulfiram) undergoes testing to confirm it matches the pharmacokinetic profile of the reference drug. Regulatory bodies require proof that the rate and extent of absorption align with the approved reference formulation.

Why do price differences exist among various multi-source formulations?

Costs fluctuate based on manufacturing logistics, supply chain overheads, and the regional market dynamics in Hong Kong. Lower costs for a generic equivalent do not imply reduced efficacy or purity if the supplier holds WHO-GMP certification.

How is the logistical routing of this medication coordinated?

The service facilitates the transport of medication from regulated, compliant sources to the end-user. This process requires existing medical authorization to ensure the patient receives appropriate oversight aligned with local health standards.

Are there variances in the physical appearance of this formulation?

Differences in tablet color, shape, or inactive binders occur between manufacturers of generic equivalents. These physical variances do not modify the active mechanism of Disulfiram (250mg or 500mg).

How does moisture affect the stability of the compound?

Humidity impacts the molecular stability and shelf-life of the chemical compound. Proper storage in the original, sealed packaging preserves the standardized potency of the product.

Are there specific import regulations for medication in Hong Kong?

The PPB strictly enforces laws governing the importation of pharmaceutical products. Patients must coordinate with their local physician to verify that the specific pathway for their medication adheres to current regulatory guidelines.

Will this medication appear on workplace drug testing?

Disulfiram (250mg or 500mg) does not share chemical structural characteristics with common illicit substances or opioids. Routine testing protocols do not target this compound, though individual testing policies vary by employer.

Pharmacological Profile of Generic Antabuse

Generic Antabuse (Disulfiram) functions as an alcohol-deterrent agent available in concentrations of 250mg and 500mg tablets. This multi-source oral formulation modifies the metabolic pathway of ethanol within the hepatic system.

The PPB (Pharmacy and Poisons Board of Hong Kong) monitors the distribution of this chemical entity. It acts as a primary tool for managing alcohol-related dependence within controlled clinical programs.

Biochemical Modulation of Ethanol Metabolism

Disulfiram inhibits the activity of the enzyme aldehyde dehydrogenase. This blockade prevents the healthy oxidation of acetaldehyde-a toxic byproduct of alcohol metabolism-into acetate.

Acetaldehyde accumulates rapidly in the bloodstream when ethanol consumption occurs during active therapy. This elevated concentration of acetaldehyde triggers a systemic physiological response. The mechanism relies strictly on the presence of alcohol to initiate cellular symptoms.

Regulatory Indications and Usage

The PPB approves Generic Antabuse (Disulfiram) for the supportive management of alcohol dependence. It serves as an adjunctive therapy within comprehensive programs involving psychological support and clinical monitoring. Healthcare providers utilize this medication to foster abstinence by conditioning a negative physiological reaction to ethanol consumption.

Contraindications

Pregnancy and Developmental Risks

Consult a physician before considering this medication, as the potential impact on human fetal development and lactation remains clinically significant. Regulatory monitoring classifies this compound as requiring strict medical supervision during all stages of gestation.

Severe Cardiovascular Conditions

Individuals with significant coronary artery disease or a history of heart failure face heightened risks. Disulfiram-ethanol interactions induce tachycardia-a rapid heart rate-which burdens the cardiovascular system.

Comorbid Liver Pathology

Metabolic activation of the compound occurs primarily in the liver. Patients with established hepatic dysfunction require extensive clinical evaluation to identify potential risks of localized or systemic injury.

Adverse Events

Common Reactions

Patients may report metallic or garlic-like taste sensations. Neurological changes, such as drowsiness or cognitive fatigue, occasionally manifest during the onset of therapy.

Serious Reactions

Hepatotoxicity-damage to liver cells-is a clinical concern necessitating periodic monitoring of liver enzyme profiles. Rare reports of peripheral neuropathy and optic neuritis require immediate cessation and clinical assessment.

Drug Interactions

Disulfiram significantly alters the metabolism of concurrent medications, including warfarin, phenytoin, and caffeine. The inhibition of cytochrome P450 enzymes causes elevated concentrations of these chemicals in the plasma.

Routes of Administration

Administered orally via tablets. Swallow the pill whole with water. All timing and total daily quantity decisions remain the sole responsibility of a licensed physician.

Storage Requirements

Store in a cool, dry environment away from high temperatures or moisture. Keep the container sealed to maintain the chemical integrity of the formulation. Dispose of expired or unused medication through established clinical waste disposal channels in Hong Kong.

Medical and Access Disclaimer

This documentation provides pharmacological information and does not replace medical advice, diagnosis, or clinical treatment. Consult a licensed healthcare provider in Hong Kong before starting or altering any prescribed therapy. This service coordinates logistical routing through WHO-GMP compliant pharmacies for users who maintain a valid physician authorization. We recommend reviewing local medical subsidies through the Hospital Authority before seeking external sources. This framework acts strictly as a secondary clinical resource. Licensed professionals in regulated jurisdictions perform all dispensing to support the continuity of care established by your local doctor.

Glossary

Aldehyde dehydrogenase
An enzyme that facilitates the conversion of toxic acetaldehyde into harmless acetate during liver metabolism.
Cytochrome P450
A group of liver enzymes that facilitate the breakdown and processing of various chemicals and medications.
Hepatic
Relating to the functions and clinical conditions of the liver.
Metabolism
The set of life-sustaining chemical processes that transform consumed substances into energy or waste within the body.
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