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Roflumilast is a once-daily tablet for severe COPD with chronic bronchitis, sold here as 500 microgram tablets to lower the number of flare-ups.
Roflumilast
500mcg
Roflumilast 500mcg tablets, taken once a day to reduce flare-ups in severe COPD with chronic bronchitis, supplied in packs of 30 to 180.
Roflumilast is added to treatment for severe COPD — chronic obstructive pulmonary disease, the long-term lung damage that narrows the airways — when the person also has chronic bronchitis (a daily cough with phlegm) and has had flare-ups. Taken every day, it reduces how often those flare-ups happen. It is not a bronchodilator and won't ease a sudden attack of breathlessness; a reliever inhaler does that job. The benefit builds over days to weeks, so a first tablet does not feel like anything.
The enzyme phosphodiesterase-4 (PDE4) sits inside the inflammatory cells that crowd the airways in COPD and breaks down a signalling molecule called cyclic AMP. Roflumilast blocks that enzyme, cyclic AMP rises, and the cells release fewer of the substances that keep the bronchial tubes swollen and irritable. Because it works on that slow process rather than on muscle tone in the airway, it is a background treatment, not something for a bad breathing day.
Roflumilast tablets are the 500 microgram strength, taken as one tablet a day at roughly the same point in the day, and food does not matter. Some courses begin on a 250 microgram tablet for four weeks and then step up to 500 micrograms; 500 micrograms is the dose that does the work. If a day is missed, taking the tablet later the same day is fine — but not two together.
Diarrhoea, nausea, headache, back pain, dizziness, a reduced appetite, muscle spasm, shaky hands and trouble sleeping are the ones most often reported, and they tend to ease as the body settles. Weight loss is common enough that it is worth weighing yourself now and then — losing weight steadily without meaning to is a reason to review the treatment. Less common but more serious: new or worsening low mood, anxiety, agitation or thoughts of harming yourself, which can develop during treatment and are a known reason for stopping it.
Rifampicin, carbamazepine, phenytoin and phenobarbital — strong inducers of liver enzymes — speed roflumilast out of the body and are not used with it. The opposite happens with medicines such as erythromycin, ketoconazole and cimetidine, which slow its breakdown and can make side effects more likely. Roflumilast is also not used by people whose liver is moderately or severely impaired, since the liver clears the drug. The asthma and respiratory section holds the other daily treatments for COPD and asthma.
Roflumilast can be ordered online with delivery to Hong Kong. The page lists Roflumilast tablets. Tracked courier delivery to Hong Kong takes 5 to 9 business days and comes with online tracking.
Roflumilast is priced per pack: its page lists every strength and pack size with the current price in HKD or your chosen currency.
PockDose does not ask you to upload a prescription when you order roflumilast. See the ordering FAQ for details.
Daliresp is a brand name of roflumilast, which is also sold as Daxas. Here, roflumilast can be bought online as roflumilast tablets. These are generics, not the original brand.
Its effect builds over days to weeks rather than hours, and the benefit is measured over months of daily use as fewer COPD flare-ups. There is nothing to feel after a single tablet, which is why it is taken continuously instead of only on days when breathing is worse.
Yes in substance — Daliresp is a brand name for roflumilast, so both contain the same active ingredient in a 500 microgram tablet. Only the name printed on the pack differs; what is inside does not.
The 250 microgram tablet is a starting strength used for the first four weeks of treatment; 500 micrograms is the maintenance dose that reduces flare-ups, and it is the strength sold here as a once-daily tablet.
No. It belongs to a class called phosphodiesterase-4 inhibitors, and it is swallowed as a tablet rather than inhaled. Steroids and bronchodilators work in different ways, and roflumilast is added on top of them in severe COPD rather than replacing them.
No — it controls the condition rather than curing it, and it does not restore lost lung function. People generally stay on it long term, with the aim of fewer flare-ups and steadier breathing from day to day.