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Saxagliptin is a DPP-4 inhibitor for type 2 diabetes; PockDose sells it combined with metformin as generic Kombiglyze XR extended-release tablets in 5mg/500mg and 5mg/1000mg.
Saxagliptin, Metformin
5/500/5/1000mg
Generic Kombiglyze XR is a saxagliptin and metformin extended-release tablet for type 2 diabetes, sold as 5mg/500mg and 5mg/1000mg tablets taken once a day with the evening meal.
Saxagliptin is a gliptin, the everyday name for DPP-4 inhibitors, used in adults with type 2 diabetes alongside diet and exercise. After a meal the gut releases incretin hormones that prompt the pancreas to release insulin and ask the liver to ease off glucose. An enzyme called DPP-4 clears those hormones within minutes. Saxagliptin blocks that enzyme, so the signal lasts longer, and the effect fades once blood sugar is back to normal. That is why a gliptin seldom drops sugar too low by itself. Sitagliptin and linagliptin belong to the same class. None of them treats type 1 diabetes or diabetic ketoacidosis.
One listing carries it: Kombiglyze XR, an extended-release tablet pairing saxagliptin with metformin in 5mg/500mg and 5mg/1000mg. Both strengths hold 5mg of saxagliptin, and the metformin part, 500mg or 1000mg, is the only thing that changes. Saxagliptin on its own is not listed, but the diabetes category has the other medicines for type 2 diabetes.
Headache, a sore throat or blocked nose, and urinary tract infections come up most. Joint pain can turn severe, and a few people develop skin blisters; both are reasons to stop the tablets. One large trial linked saxagliptin to more hospital admissions for heart failure, so breathlessness when lying flat, swollen ankles or a sudden jump in weight matter. Sudden, severe pain high in the stomach that spreads to the back, sometimes with vomiting, can be pancreatitis and needs urgent treatment. Swelling of the lips, face or throat points to an allergic reaction.
Added to insulin or a sulfonylurea, saxagliptin makes low blood sugar more likely: shaking, sweating, hunger and a racing heart are the signs.
Strong blockers of the CYP3A4 liver enzyme, such as ketoconazole, itraconazole, clarithromycin and ritonavir, raise saxagliptin levels, and the usual advice with them is a lower saxagliptin amount than the 5mg in these tablets. The kidneys clear part of the drug too, so reduced kidney function pushes levels up. A past serious allergic reaction to a gliptin rules saxagliptin out. In the combination tablet, metformin brings limits of its own, mostly around kidney function.
Saxagliptin can be ordered online with delivery to Hong Kong. The page lists generic Kombiglyze XR tablets in 5/500mg and 5/1000mg. Tracked courier delivery to Hong Kong takes 5 to 9 business days and comes with online tracking.
Kombiglyze XR is priced per pack: its page lists every strength and pack size with the current price in HKD or your chosen currency.
PockDose does not ask you to upload a prescription when you order saxagliptin. See the ordering FAQ for details.
Kombiglyze XR is a brand name of saxagliptin and metformin. Here, saxagliptin and metformin can be bought online as generic Kombiglyze XR. These are generics, not the original brand.
Onglyza is a brand name for saxagliptin on its own. The saxagliptin tablet on PockDose is the combination with metformin, generic Kombiglyze XR, so there is no plain single-ingredient saxagliptin tablet here.
They work on different steps. Metformin mainly lowers the glucose the liver makes and improves insulin response, while saxagliptin lengthens the gut hormone signal that releases insulin after meals. That is why the two are often combined in one tablet.
Gliptins such as saxagliptin are generally weight-neutral, meaning they do not usually add or remove weight. Weight changes are more often linked to other diabetes medicines taken with it, such as insulin or sulfonylureas.