Kombiglyze XR
Generic Kombiglyze XR is a saxagliptin and metformin extended-release tablet for type 2 diabetes, sold as 5mg/500mg and 5mg/1000mg tablets taken once a day with the evening meal.
All strengths and pack prices
| Strength | Pack | Price | Per tablet |
|---|---|---|---|
| 5/500mg | 14 tablets | $72.24 | $5.16 |
| 5/500mg | 28 tablets | $140.28 | $5.01 |
| 5/500mg | 56 tablets | $276.08 | $4.93 |
| 5/500mg | 84 tablets | $410.76 | $4.89 |
| 5/500mg | 112 tablets | $542.08 | $4.84 |
| 5/500mg | 168 tablets | $821.52 | $4.89 |
| 5/1000mg | 14 tablets | $82.46 | $5.89 |
| 5/1000mg | 28 tablets | $160.72 | $5.74 |
| 5/1000mg | 56 tablets | $319.20 | $5.70 |
| 5/1000mg | 84 tablets | $474.60 | $5.65 |
| 5/1000mg | 112 tablets | $628.32 | $5.61 |
| 5/1000mg | 168 tablets | $932.40 | $5.55 |
- Category
- Diabetes Management
- Active ingredient
- Saxagliptin · Metformin
- Route
- Oral
- Form
- Extended-release tablet
- Strengths
- 5/500/5/1000mg
You will receive a quality generic equivalent, depending on stock.
Shipped in a discreet, unmarked envelope.
Details
- Conditions
- Type 2 diabetes mellitus
- Therapeutic Class
- DPP-4 Inhibitor, Biguanide
- Pharmacological Class
- Antidiabetic
- Minor Side Effects
- Headache, Upper respiratory infection
- Moderate Side Effects
- Diarrhoea, Nausea, Stomach upset
- Dosage Forms
- Extended-release tablet
- Administration Route
- Oral
- Originator
- AstraZeneca
- Onset Time
- Steady state over several days
- Duration
- 24 hours
- Storage Instructions
- Store at room temperature, keep dry.
- Drug Interactions
- Diuretics, Corticosteroids
What you will receive
Kombiglyze XR is the originator brand name, made by AstraZeneca. We use it to identify the medicine; the pack you receive is a generic equivalent, not the original Kombiglyze XR.
- The same active ingredient (Saxagliptin / Metformin) at the same strength.
- The exact brand supplied depends on what is in stock when your order ships.
FAQ
Which strengths and pack sizes of generic Kombiglyze XR can I order?
Generic Kombiglyze XR tablets come in 5/500mg and 5/1000mg strengths. You can order packs of 14, 28, 56, 84, 112 or 168 tablets. It is generic saxagliptin + metformin, not the original Kombiglyze XR. Larger packs cost less per tablet.
How is Kombiglyze XR delivered to Hong Kong?
For Kombiglyze XR, if a parcel does not arrive within its delivery window, or arrives damaged, it is sent again free; if that is not possible, the order is refunded. Card details never reach the shop's servers when you pay by Visa, Mastercard or American Express on the secure, encrypted payment page.
Is Kombiglyze XR the same as taking saxagliptin and metformin separately?
It contains the same two medicines in one tablet, so you handle one daily dose instead of two bottles. Both strengths keep saxagliptin at 5mg; the metformin amount, 500mg or 1000mg, is what differs between them.
Can I split or crush Kombiglyze XR?
No. The tablet is extended-release, and breaking or chewing it lets the metformin and saxagliptin out all at once instead of slowly. Swallow it whole with a drink, along with your evening meal.
Does Kombiglyze XR cause low blood sugar?
On its own it seldom does, because neither ingredient forces insulin out when sugar is normal. The chance goes up when it is added to insulin or a sulfonylurea tablet such as glimepiride or gliclazide, or when meals are skipped.
Can I drink alcohol while taking Kombiglyze XR?
Regular heavy drinking and binge drinking are the problem. Alcohol adds to the lactic acid risk that comes with metformin and can push blood sugar down, so it is better kept light or left out.
About Kombiglyze XR
One tablet, two diabetes medicines
Say you take saxagliptin in the morning and metformin with dinner and would rather deal with one tablet. That is what Kombiglyze XR is: both medicines in a single extended-release tablet for type 2 diabetes. Saxagliptin is a DPP-4 inhibitor and metformin is a biguanide. Each tablet has 5mg of saxagliptin plus either 500mg or 1000mg of metformin, hence the strengths 5mg/500mg and 5mg/1000mg. It goes with diet and exercise and is not used for type 1 diabetes.
What each half does
Saxagliptin and metformin lower blood sugar in different ways, which is why they are paired. Saxagliptin stops the gut hormones that trigger insulin after a meal from being broken down so quickly. Metformin tells the liver to release less sugar. Neither forces insulin out when your sugar is already normal, so lows are uncommon, except when the tablet is added to insulin or a sulfonylurea like glimepiride. There is more on saxagliptin itself on the saxagliptin page.
Taking it
Swallow one tablet whole with the evening meal. Do not halve it to get a smaller amount, because splitting or chewing an extended-release tablet defeats the slow release. The two strengths share the same 5mg of saxagliptin, and the 5mg/1000mg tablet has double the metformin of the 5mg/500mg one, so metformin is the amount you are choosing between.
Side effects and cautions
In the first weeks the stomach is where most people notice it: diarrhoea, nausea, discomfort and a metallic taste from the metformin, usually fading with time. Saxagliptin brings sore throats, blocked noses, headaches and urinary infections. Some people cannot use the tablet at all, because severely reduced kidney function and diabetic ketoacidosis rule it out and heavy drinking counts against it. If you are booked for a scan with iodine contrast dye, metformin is paused around it.
Two rare problems need urgent treatment: lactic acidosis, a build-up of acid in the blood with extreme tiredness, fast deep breathing and muscle or stomach pain, and pancreatitis, with severe stomach pain spreading to the back. Breathlessness with swollen ankles can point to heart failure, which saxagliptin has been linked to. Ketoconazole and some HIV medicines raise saxagliptin levels, and topiramate or acetazolamide add to metformin's lactic acid risk.
Sources
- Saxagliptin: MedlinePlus Drug Information — MedlinePlus / U.S. National Library of Medicine
- Metformin: MedlinePlus Drug Information — MedlinePlus / National Library of Medicine