Entresto
Entresto (generic sacubitril and valsartan) is a twice-daily tablet for chronic heart failure with reduced ejection fraction; order 97mg/103mg tablets in packs of 14, 28 or 56.
All strengths and pack prices
| Strength | Pack | Price | Per tablet |
|---|---|---|---|
| 97/103mg | 14 tablets | $35.70 | $2.55 |
| 97/103mg | 28 tablets | $56.84 | $2.03 |
| 97/103mg | 56 tablets | $100.24 | $1.79 |
- Category
- Heart & Blood Pressure
- Active ingredient
- Sacubitril · Valsartan
- Route
- Oral
- Form
- Tablet
- Strengths
- 97/103mg
You will receive a quality generic equivalent, depending on stock.
Shipped in a discreet, unmarked envelope.
Details
- Therapeutic Class
- Neprilysin Inhibitor / ARB
- Pharmacological Class
- Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
- Minor Side Effects
- Dizziness, Cough
- Moderate Side Effects
- Low blood pressure, Increased potassium levels
- Dosage Forms
- Tablet
- Administration Route
- Oral
- Originator
- Novartis
- Onset Time
- 1 week (clinical effect)
- Duration
- 12 hours
- Storage Instructions
- Store away from moisture.
- Drug Interactions
- ACE inhibitors, Potassium supplements, Aliskiren
- Age Restrictions
- Not for children.
What you will receive
Entresto is the originator brand name, made by Novartis. We use it to identify the medicine; the pack you receive is a generic equivalent, not the original Entresto.
- The same active ingredient (Sacubitril / Valsartan) at the same strength.
- The exact brand supplied depends on what is in stock when your order ships.
FAQ
Which Entresto pack sizes can I order?
Entresto tablets are available as generic sacubitril + valsartan in 97/103mg. Pack sizes are 14, 28 or 56 tablets. The pack contains generic sacubitril + valsartan, not the original Entresto. Larger packs cost less per tablet.
How do I pay for Entresto and receive it in Hong Kong?
You can pay for Entresto by Visa, Mastercard or American Express on a secure, encrypted payment page, or by Bitcoin or Ethereum. Card details never reach the shop's servers. Support answers 24/7 in English and Cantonese by live chat.
What is another name for sacubitril and valsartan?
Entresto and Vymada are brand names of sacubitril and valsartan. Here, sacubitril and valsartan can be bought online as generic Entresto. These are generics, not the original brand.
How is Entresto different from an ACE inhibitor?
An ACE inhibitor only blocks the angiotensin pathway. Entresto does that through valsartan and also stops neprilysin breaking down the heart's own protective peptides. In the large trial against enalapril it cut heart deaths and admissions more.
Should I keep taking Entresto when I feel better?
Yes. Heart-failure medicines control the condition without curing it, and feeling well is usually a sign they are working. Stopping can let breathlessness and swelling come back.
What should I do about dizziness on Entresto?
Stand up slowly and sit down if it hits. Lightheadedness comes from lower blood pressure and is most common after starting or moving up a strength. Alcohol and hot baths make it worse.
Does Entresto need blood tests?
Yes. Potassium and kidney function are checked by blood test, usually after starting and after each step up in strength, because both can move on this medicine.
About Entresto
Entresto 97mg/103mg for heart failure
Entresto is aimed at a particular problem: chronic heart failure where the heart muscle pumps weakly, known as reduced ejection fraction (a lower share of the blood in the heart is pushed out with each beat). The tablets here are generic, each one holding 97mg of sacubitril and 103mg of valsartan. Taken with the rest of heart-failure treatment, such as a beta-blocker, it is used to lower the chance of dying from heart causes and of being admitted to hospital with worsening heart failure. The 97mg/103mg tablet is the top strength of the range, the one people usually work up to by stepping through smaller tablets over several weeks.
What the two halves do
Ankles swollen by evening, breathless on the stairs: that is salt and water backing up behind a tired heart. Two hormone systems pull in opposite directions here.
The heart's own peptides tell the kidneys to shed salt and water and tell vessels to relax. An enzyme, neprilysin, keeps breaking them down. Sacubitril blocks that enzyme, so the signals last. Angiotensin II does the reverse, tightening vessels and holding salt. Valsartan stops it. Less resistance, less load.
Taking it
One tablet is taken twice a day, about 12 hours apart, with or without food. Taking it with breakfast and the evening meal makes the times easy to keep. Entresto does not bring a quick change in how you feel; it is a long-term treatment, and it should be continued on days when symptoms are quiet.
The warnings that matter most
Entresto must never be taken alongside an ACE inhibitor (ramipril, enalapril, lisinopril and similar); a gap of 36 hours after the last ACE inhibitor tablet is needed, because the combination can cause dangerous swelling. It is also not used in pregnancy, as it can harm the baby.
Dizziness and low blood pressure, higher potassium, a change in kidney readings and a cough are the usual effects. Swelling of the face, lips, tongue or throat, or trouble breathing, needs urgent treatment. Potassium supplements, potassium-based salt substitutes and some water tablets add to the potassium effect, and alcohol adds to the dizziness.
The compound itself is explained on the sacubitril page.
Sources
- Sacubitril and Valsartan: MedlinePlus Drug Information — MedlinePlus / U.S. National Library of Medicine
- Valsartan: MedlinePlus Drug Information — National Library of Medicine