Letairis
Letairis is ambrisentan, a once-daily tablet for pulmonary arterial hypertension that aims to improve exercise capacity, available as 5mg and 10mg tablets in packs of 30, 60 or 90.
All strengths and pack prices
| Strength | Pack | Price | Per tablet |
|---|---|---|---|
| 5mg | 30 tablets | $420.90 | $14.03 |
| 5mg | 60 tablets | $821.40 | $13.69 |
| 5mg | 90 tablets | $1,221.30 | $13.57 |
| 10mg | 30 tablets | $688.50 | $22.95 |
| 10mg | 60 tablets | $1,254.60 | $20.91 |
| 10mg | 90 tablets | $1,857.60 | $20.64 |
- Category
- Heart & Blood Pressure
- Active ingredient
- Ambrisentan
- Route
- Oral
- Form
- Tablet
- Strengths
- 5/10mg
You will receive a quality generic equivalent, depending on stock.
Shipped in a discreet, unmarked envelope.
Details
- Therapeutic Class
- Endothelin receptor antagonist
- Pharmacological Class
- Antihypertensive
- Minor Side Effects
- Headache, nasal congestion
- Moderate Side Effects
- Flushing, palpitations
- Dosage Forms
- Tablet
- Administration Route
- Oral
- Originator
- Gilead Sciences
- Onset Time
- Hours to weeks
- Duration
- 24 hours
- Storage Instructions
- Store at controlled room temperature.
- Drug Interactions
- Strong CYP3A inhibitors
What you will receive
Letairis is the originator brand name, made by Gilead Sciences. We use it to identify the medicine; the pack you receive is a generic equivalent, not the original Letairis.
- The same active ingredient (Ambrisentan) at the same strength.
- The exact brand supplied depends on what is in stock when your order ships.
FAQ
Which Letairis strengths and pack sizes are available?
Letairis comes as tablets in 5mg and 10mg, in packs of 30, 60 or 90. It is generic ambrisentan, not the original Letairis. Larger packs cost less per tablet.
What happens if my Letairis parcel does not arrive?
If your Letairis parcel does not arrive within the delivery window, or arrives damaged, we send it again free, and if that is not possible the order is refunded. Payment is by Visa, Mastercard or American Express on a secure, encrypted page, or with Bitcoin or Ethereum.
What are the alternative names for Letairis and ambrisentan?
Letairis is a brand name of ambrisentan, which is also sold as Volibris. Here, ambrisentan can be bought online as generic Letairis. These are generics, not the original brand.
Is Letairis the same as ambrisentan?
They are the same ingredient. Letairis is simply a brand name for ambrisentan, and the tablets sold here are generic ambrisentan in 5mg and 10mg, one a day, for pulmonary arterial hypertension.
What other medicines interact with Letairis?
Cyclosporine is the one with a clear effect: it raises ambrisentan levels in the blood, so a smaller ambrisentan dose may be used. Tadalafil, by contrast, is a common partner, since the two are taken together for PAH.
What should I do if I miss a dose of Letairis?
Take the forgotten tablet when you remember, provided the next day's dose is not already due. If two doses would end up close together, leave the missed one out and carry on as usual rather than taking two at once.
How long will I need to take Letairis?
PAH is a long-term condition and ambrisentan is a long-term treatment. It eases symptoms and slows worsening but does not cure the disease, so most people stay on it for years. Stopping abruptly can make breathlessness and other symptoms worse, which is why any change is planned ahead.
How should I store Letairis tablets?
Keep the tablets in their sealed blister strips, out of direct sun and away from warm appliances; a hot kitchen windowsill is a poor home for them. Tablets decanted into a weekly pill organiser for a long stretch can soften. Use the oldest pack first.
About Letairis
What Letairis is taken for
Letairis is the brand name for ambrisentan, a once-daily tablet used in pulmonary arterial hypertension (PAH) — high blood pressure in the arteries that carry blood from the heart to the lungs. Narrowed lung arteries make the right side of the heart work harder and leave people breathless on stairs, hills or a brisk walk. Ambrisentan improves how much exercise a person can manage and slows the worsening of PAH symptoms. It eases the condition rather than clearing it, so it is taken long term.
How ambrisentan works
In PAH the lung arteries are squeezed too tightly, partly because of endothelin, a protein that tells the muscle in vessel walls to contract. Ambrisentan sits on the receptor that endothelin would otherwise bind to. With that signal blocked, the walls loosen and the heart faces less resistance. Think of it as a gradual gain in how easily you breathe during daily activity, not something you feel at once.
Fitting the tablet into your day
Ambrisentan is taken once a day, and most people do best attaching it to something they already do at the same hour — the first cup of tea, or brushing teeth at night. Food makes no difference to how much of the drug is absorbed, so meals need no planning around it. Swallow the tablet whole rather than splitting, chewing or crushing it. Treatment usually begins at 5mg and steps up to 10mg if more is needed, and it is not stopped abruptly, because PAH symptoms can flare when the drug is withdrawn.
What side effects people notice
Flushing, a blocked nose and sinus pressure are the complaints mentioned most often, along with swollen ankles and feet where fluid collects in the tissues — oedema. Anaemia (a shortage of red blood cells) can develop too, showing up as unusual tiredness. The liver is the organ to watch: persistent nausea, pain below the ribs on the right, dark urine or yellowing of the skin and eyes are signs that it is being affected. Ambrisentan can harm an unborn baby, so it is not taken during pregnancy.
Choosing a strength
The tablets are 5mg or 10mg, and each strength comes in packs of 30, 60 or 90. Since the dose is one tablet a day, a 90-pack covers about three months. Order the strength you already take: both are ambrisentan, just at different amounts. Treatment normally starts at 5mg.
Sources
- Ambrisentan: MedlinePlus Drug Information — MedlinePlus / U.S. National Library of Medicine
- Ambrisentan (Letairis) - PH Association — phassociation.org